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Problem: Cigarette is too Tight Symptoms: Difficult to draw, tube splits during injection, or machine struggles to inject

As tolerance develops, more and more nicotine is needed to produce the same pleasurable effect, and smoking cessation leads to an emotional crash

Archived from the original on September 30, 2009

Intravenous nicotine self-administration also allows for the precise quantification of the amount of nicotine infused by the animal (69), but there are translational limits with this approach as humans typically inhale most nicotine-containing products

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